The Hippocampal Navigational Fuse (HNF) is a theoretical neural mechanism that selectively disrupts spatial navigation while maintaining other cognitive functions. It is hypothesized to involve the coordinated action of multiple brain regions, including the hippocampus, prefrontal cortex, and medial temporal lobe. When active, the HNF is believed to create a "circuit break" in the brain, interrupting the flow of spatial information necessary for navigation. This can lead to impairments in spatial memory, wayfinding, and the ability to form cognitive maps. The HNF is thought to play a role in various neurological and psychiatric conditions, including Alzheimer's disease, schizophrenia, and post-traumatic stress disorder, which are characterized by disruptions in spatial navigation and other cognitive functions.
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